Publications
I employ cutting-edge mass spectrometry methods to study the physical structure and function of bio-molecular machines.
These methods characterize the gas-phase behavior of protein complexes, revealing their structural features and the stoichiometry of post-translational modifications, enzymatic cofactors, and metal ions.
Mass of the Intact Molecular Machine.
Dissociation of the molecule to reveal its components.
Fragmentation of each component for confident identification.
Nuc-MS: Epigenetic analysis of whole nucleosomes. Art by www.nicoleethen.com
Analysis of proteins in methane-eating bacteria
Method to analyze antibody therapeutics in Bio-Pharma
Standard protocols to disseminate native MS
'Native proteomics' : decoding the composition of protein complexes
Standards and Benchmarks for Top-Down MS
Metal content analysis of protein that synthesizes the natural product Methanobactin